Syntheses, Structures and Biological Activites of Organogermaniun and Organotin Derivatives of Hydroxamic Acids

OF ORGANOGERMANIUM AND ORGANOTIN DERIVATIVES OF HYDROXAMIC ACIDS Valery S. Petrosyan*, Natalia S. Yashina, and Sergei V. Ponomarev Department of Chemistry, M. V. Lomonosov University, Moscow 119899, Russia Hydroxamic acids as the precursors oftheir organogermanium and organotin derivatives have been themselves intensively studied fi’om the viewpoint of their potential biological activities [1-3]. The wide spectrum of biological activities, from fungicide, bactericide and antiflammatory to psychotropic and antitumor, has been demonstrated for various organic derivatives of hydroxamic acids. Mironov and coworkers [4] at first obtained the C-germylated hydroxamic acids with about 70% yield by the reaction of the methyl ester of 3-trimethylgermylpropionic acid with hydroxylamine chlorohydrate: 0C Me3GeCH2CH2COOCH3 + NH2OH HC1 Me3GeCH2CH2CONHOH HC1 KOH